G807 Structural and Chemical Biology (First two modules of Spring I):
This course will explore the fundamentals of macromolecular structure and chemical biology with an emphasis on the underlying principles of interactions between macromolecules and small molecules. Topics will include structural, computational, and high-throughput screening approaches to drug development, and the use of chemical tools for understanding biological processes. This course is aimed at basic science doctoral graduate students in the School of Medicine programs or others interested in graduate or GCND education. Course presentations will include PowerPoint computer and overhead presentations. Students will also be expected to read original papers specified as references for many of the lectures.
G817 Molecular basis of cell structure and function
This 2-credit course will discuss how cellular organization integrates fundamental processes that control cell growth and movement. This will involve an initial discussion of how cells form cytoskeletal networks that dictate their architecture both directly and indirectly through organizing protein and lipid trafficking during static, moving and dividing cells. The formation and function of organelles and how cellular materials are moved between different intracellular compartments is then examined. The last part of the course examines the basic mechanisms governing the cell cycle and how this is controlled by cellular responses to the microenvironment. Overall, this course will provide a strong foundation for understanding the basic cellular processes that are dysregulated in disease states such as cancer. Classes will involve a mix of lectures and discussion of important literature on these topics.
G848 Bioinformatic Applications to Proteomics and Genomics (Last 2 modules of Spring I):
Biology has been transformed by various high-throughput technologies (genomics, proteomics, metabolomics, etc.), which in turn have led to a large number of massive databases and software analysis packages. This course focuses on the "omics" technologies, on the resulting databases and on the computational tools to analyze the data.
G852 Concepts of Cancer Biology: Signaling Gone Awry (Last 2 modules of Spring I):
This course will provide the fundamentals of cancer biology. It will take the perspective that cancer arises from endogenous changes in oncogenes or proto-oncogenes and/or changes resulting from the introduction of exogenous genetic material. These changes, in turn, have an impact on signaling within the cell and between cells. As such, topics covered will include: altered membrane receptor and cytoplasmic signaling; altered cell: cell interactions; dysregulated cell cycle entry; failure of cell cycle arrest, apoptosis, and senescence; angiogenesis; and altered cellular adhesion. This course is aimed at basic science doctoral graduate students in the School of Medicine programs or others interested in graduate or GCND education. Course presentations will include PowerPoint computer and overhead presentations. Student will also read, present and discuss original and review articles relevant to classes and learn how discoveries have lead to the development of biochemical assays.
Instructor: Lawrence Quilliam
Prerequisites: Completion of the BioMed I, II & III courses or consent of instructor
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