Senior Research Professor

Department of Biochemistry and Molecular Biology
Indiana University School of Medicine
Health Information and Translational Sciences Building
410 W. 10th Street, HS5009
Indianapolis, Indiana 46202

Phone: (317) 278-6448
Facsimile: (317) 278-9217
E-mail: vuversky@iupui.edu

M.S. in Physics, 1986, Leningrad State University, St. Petersburg, Russia
Ph.D. in Biophysics, 1991, Moscow Institute of Technical Physics, Moscow, Russia
D.Sc. in Biophysics, 1998, Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

Area of Study

Protein folding, non-folding and misfolding.

Selected Publications

Dr. Uversky's complete CV is available here... 

Oldfield C.J., Meng J., Yang, J.Y., Yang, M.Q., Uversky V.N., Dunker A.K. (2008) Flexible nets:  Disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics. 9 (Suppl. 1), S1.

Uversky V.N., Oldfield C.J., Dunker A.K. (2008) Intrinsically disordered proteins in human diseases: Introducing the D² concept.  Ann. Rev. Biophys. Biomol. Structure. 37, 215-246.

Dunker A.K., Uversky V.N. (2008) Signal transduction via unstructured protein conduits. Nature Chemical Biology. 4 (4), 229-230.

Mohan A., Sullivan W.J. Jr., Radivojac P., Dunker A.K., Uversky V.N. (2008) Intrinsic disorder in pathogenic and non-pathogenic microbes: Discovering and analyzing the unfoldomes of early-branching eukaryotes. Molecular Biosystems. 4 (3), 328 - 340.

Prokhorov D.A., Timchenko A.A., Uversky V.N., Khristophorov V.S., Kihara H., Kimura K., Kutyshenko V.P. (2008) Dynamics of oligomer formation by denatured carbonic anhydrase II. Biochim. Biophys. Acta - Proteins and Proteomics. 1784 (5), 834-842.

Tóth-Petróczy A., Mészáros B., Simon I., Dunker A.K., Uversky V.N., Fuxreiter M. (2008) Assessing conservation of disordered regions in proteins. The Open Proteomics Journal. 1 (1), 46-53.

Uversky V.N. (2008) Amyloidogenesis of natively unfolded proteins. Current Alzheimer Research. 5 (3), 260-287.

Paliy O., Gargac S.M., Cheng Y., Uversky V.N., Dunker A.K. (2008) Protein disorder is positively correlated with gene expression in E. coli. Journal of Proteome Research. 7 (6), 2234-2245.

De Biasio A., Guarnaccia C., Popovic M., Uversky V.N., Pintar P., Pongor S. (2008) Prevalence of intrinsic disorder in the intracellular region of human single-pass type I proteins: The case of the Notch ligand Delta-4. Journal of Proteome Research. 7 (6), 2496-2506.

Singh V.K., Pacheco I., Uversky V.N., Smith S.P., MacLeod R.J., Jia Z. (2008) Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J. Mol. Biol. 380 (2), 313-326.

Permyakov S.E., Bakunts A.G., Denesyuk A.I., Knyazeva E.L., Uversky V.N. Permyakov E.A. (2008) Apo-parvalbumin as an intrinsically disordered protein. POTEINS Structure, Function, and Bioinformatics. 72 (3), 822-836.

Rantalainen K., Uversky V.N., Permi P., Kalkkinen N., Dunker A.K., Mäkinen K. (2008) Potato virus A genome-linked protein VPg is an intrinsically disordered molten globule-like protein with a hydrophobic core. Virology. 377 (2), 280-288.

Xu M., Ermolenkov V.V., Uversky V.N., Lednev I.K. (2008) Hen egg white lysozyme fibrillation: A deep UV resonance Raman spectroscopic study. Journal of Biophotonics. 1 (3), 215-229.

Dunker A.K., Oldfield, C.J., Meng J., Romero P., Yang, J.Y., Cheng J.W., Vacic V., Obradovic Z., Uversky V.N. (2008) The unfoldomics decade: An update on intrinsically disordered proteins. BMC Genomics. 9 (Suppl. 2), S1.

Goh G.K.-M., Dunker A.K., Uversky V.N. (2008) Protein intrinsic disorder toolbox for comparative analysis of viral proteins. BMC Genomics. 9 (Suppl. 2), S4.

Ren S., Uversky V.N., Chen Z., Dunker A.K., Obradovic Z. (2008) Short Linear Motifs recognized by SH2, SH3 and S/T Kinase domains are conserved in disordered protein regions. BMC Genomics. 9 (Suppl. 2), S26.

Durand F., Dagkessamanskaia A., Martin-Yken H., Graille M., Van Tilbeurgh H., Uversky V.N., Francois J.M. (2008) Structure-function analysis of Knr4/Smi1, a newly member of intrinsically disordered proteins family, indispensable in the absence of a functional PKC1-SLT2 pathway in Saccharomyces cerevisiae. Yeast. 25 (8), 563-676.

Stepanenko O.V., Verkhusha V.V, Kuznetsova I.M., Uversky V.N., Turoverov K.K. (2008) Fluorescent proteins as biomarkers and biosensors: Throwing color lights on molecular and cellular processes. Current Protein and Peptide Science. 9 (4), 338-369.

Meng X., Fink A.L., Uversky V.N. (2008) The effect of membranes on the in vitro fibrillation of an amyloidogenic light chain variable domain SMA. J. Mol. Biol. 381 (4), 989-999.

Hu D., Qin Z., Xue B., Fink A.L., Uversky V.N. (2008) Effect of methionine oxidation on structural properties, conformational stability and aggregation of immunoglobulin light chain LEN. Biochemistry. 47 (33), 8665-8677.

Munishkina L.A., Ahmad A., Fink A.L., Uversky V.N. (2008) Guiding protein aggregation with macromolecular crowding. Biochemistry. 47 (34), 8993-9006.

Cortese M.S., Uversky V.N., Dunker A.K. (2008) Intrinsic disorder in scaffold proteins: Getting more from less. Progress in Biophysics & Molecular Biology. 98 (1), 85-106.

Hong D.-P., Fink A.L., Uversky V.N. (2008) Structural characteristics of the α-synuclein oligomers stabilized by the flavonoid baicalein. J. Mol. Biol. 383 (1), 214-223.

Stepanenko O.V., Verkhusha V.V., Shavlovsky M.M., Kuznetsova I.M., Uversky V.N., Turoverov K.K. (2008) Understanding the role of Arg96 in structure and stability of green fluorescent protein. POTEINS Structure, Function, and Bioinformatics.  73 (3), 539-551.

Uversky V.N. (2008) α-Synuclein misfolding and neurodegenerative diseases. Current Protein and Peptide Science. 9 (5), 507-540.

Campen A., Williams R.M., Brown C.J., Uversky V.N., Dunker A.K. (2008) TOP-IDP-Scale: A new amino acid scale measuring propensity for intrinsic disorder. Protein and Peptide Letters. 15 (9), 956-963.

Uversky V.N. (2008) Protein folding, misfolding and aggregation: Classical themes and novel approaches. Edited by Victor Muñoz. Book review. ChemBioChem. 9 (16), 2750-2751.

Goh G.K.-M., Dunker A.K., Uversky V.N., (2008) A comparative analysis of viral matrix proteins using disorder predictors. Virology Journal. 5, 126.

Fuxreiter M., Tompa P., Simon I., Uversky V.N., Hansen J.C., Asturias F.J. (2008) Malleable machines take shape in transcription regulation. Nature Chemical Biology. 4 (12) 728-737.

Uversky V.N., Dunker A.K. (2008) Controlled chaos. Science. 322 (2008) 1340-1341.

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Books

Protein Structures: Kaleidoscope of Structural Properties and Functions (Uversky V.N., Ed.) Research Signpost, Trivandrum, Kerala, India (2003).

Protein Misfolding, Aggregation and Conformational Diseases: I. Protein Aggregation and Conformational Disorders (Uversky, V.N., Fink, A.L., Eds.) Springer, New York, USA. (2006).

Protein Misfolding, Aggregation and Conformational Diseases: II. Molecular Mechanisms of Conformational Diseases (Uversky, V.N., Fink, A.L., Eds.) Springer, New York, USA. (2007).

Book Series

"Molecular Anatomy and Physiology of Proteins"

Permyakov E.A. (2005) α-Lactalbumin. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA.

Vial C., Ed. (2006) Creatine Kinase. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA.

Philippov P.P., Ed. (2006) Neuronal Calcium Sensor Proteins. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA.

Zerovnik E., Ed. (2006) Human stefins. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA.

Permyakov E.A. (2007) Parvalbumin. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA.

Uversky V.N., Permyakov A.E., Eds. (2007) Methods in Protein Structure and Stability Analysis: Vibrational Spectroscopy. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN-10: 1-60021-703-6; ISBN-13: 978-1-60021-703-6).
 
Uversky V.N., Permyakov A.E., Eds. (2007) Methods in Protein Structure and Stability Analysis:  Luminescence Spectroscopy and Circular Dichroism. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN-10: 1-60021-404-5; ISBN-13: 978-1-60021-404-2).
 
Uversky V.N., Permyakov A.E., Eds. (2007) Methods in Protein Structure and Stability Analysis: Conformational Stability, Size, Shape and Surface of Protein Molecules. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN-10: 1-60021-704-4; ISBN-13: 978-1-60021-704-3).
 
Uversky V.N., Permyakov A.E., Eds. (2007) Methods in Protein Structure and Stability Analysis: NMR and EPR Spectroscopies, Mass-Spectrometry and Protein Imaging. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN-10: 1-60021-705-2; ISBN-13: 978-1-60021-705-0).
 
Siddiqui K.S., Thomas T., Ed. (2008) Protein adaptation in extremophiles. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN: 978-1-60456-019-0)
 
Andersson K.K. (2008) Ribonucleotide Reductase. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN: 978-1-60456-199-9)
 
Nagradova N.K. (2008) Foldases. In series "Molecular Anatomy and Physiology of Proteins" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN: 978-1-60456-389-4).

"Molecular Anatomy and Physiology of Proteinaceous Machines"

Kataeva I.A., Ed. (2007) Cellulosome. In series "Molecular Anatomy and Physiology of Proteinaceous Machines" (Uversky V.N., series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA.

"Intrinsically Disordered Proteins"

Longhi S. (2008) Measles Virus Nucleoprotein. In series "Intrinsically Disordered Proteins" (Uversky V.N., Dunker A.K., series Eds.). Nova Science Publishers, Inc., Hauppauge, NY, USA, (ISBN 978-1-60021-629-9).

"Scientific Revolutions"

Creamer T.P. (2008) Unfolded Proteins: From Denatured to Intrinsically Disordered. In series "Scientific Revolutions" (Uversky V.N. series Ed.). Nova Science Publishers, Inc., Hauppauge, NY, USA. (ISBN 978-1-60456-107-4)

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